![]() ![]() However, the respiratory system properties, e.g., tissue elasticity, sometimes change during the experiments depending on what kind of experiment it is. As a result, the respiration airflow conditions, such as the tidal airflow volume and the frequency, are determined prior to the experiments, and these values are not normally changed during the experiment. Generally, the ventilator for small experimental animals consists of a mechanically simple piston structure, and it generates a sinusoidal shaped respiration airflow. Ventilators are used in the medical field to assist with the maintenance of breathing as a vital activity, and they are also applied to research on the respiratory system in animal experiments. The inside of the respiratory system was normally pressurized without damage, and we confirmed that the developed system was able to evaluate the elasticity of the lung tissue in the rat by using the pressure value obtained at the quasi-static conditions in the case of the ventilation in the animal experiments. A balloon made of a silicone resin with a hardness of A30 was utilized as the simulated lung system and applied to the elasticity evaluation of the respiratory system in a living rat. The artificial dead space in the system was minimized to the value of 0.11 mL by integrating the two sensors on the same plate (26.0 mm × 15.0 mm). The flow sensor was a hot-wire thermal airflow meter with a directional detection and airflow temperature change compensation function based on MEMS technology, and the pressure sensor was a commercially available one also produced by MEMS. A respiratory measurement system composed of pressure and airflow sensors was introduced to precisely control the respiratory condition during animal experiments.
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